Date

February 2024

Overview

Quadrupole time-of-flight (QTOF) mass spectrometry is an advanced analytical technique that has some capabilities that make it particularly useful in screening in toxicology cases for unknown analytes. The technology combines the power of a quadrupole mass filter with the resolution and accuracy of TOF analysis.

This document describes the process from sample introduction to TOF analysis, methods of targeted and untargeted screening, and methods of inputting common fragments and neutral losses (CF/NL) into processing by batch or individual sample. Additionally, this resource contains a modified version of CFSRE Neutral Loss and Common Fragments List with calculated fields for CFs and NLs.

Related Resources

Funding for this Forensic Technology Center of Excellence report was provided by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice.

The opinions, findings, and conclusions or recommendations expressed in this report are those of the author(s) and do not necessarily reflect those of the U.S. Department of Justice.

Contact us at ForensicCOE@rti.org with any questions and subscribe to our newsletter for notifications.

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