Introduction

Technical Note – Ultra-High Performance Liquid Chromatography Photo Diode Array Ultraviolet Single Quadrupole Mass Spectrometry (UHPLC-PDA UV-MS)

Technical Note – Ultra-High Performance Liquid Chromatography Photo Diode Array Ultraviolet Single Quadrupole Mass Spectrometry (UHPLC-PDA UV-MS)

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Date

December 2023

Overview

The National Institute of Justice (NIJ), in partnership with the Forensic Technology Center of Excellence (FTCOE) at RTI International, formed the Forensic Laboratory Needs Technology Working Group (FLN-TWG). The FLN-TWG supports NIJ’s mission to improve knowledge and understanding of the forensic technology needs of federal, state, local, and tribal forensic practitioners and crime laboratories. 

This technical note details the utility of ultra-high performance liquid chromatography (UHPLC) coupled with photo diode array ultraviolet spectroscopy (PDA UV) detection and single quadrupole mass spectrometry (MS) detection in series as a complementary technique to gas chromatography-electron ionization-mass spectrometry (GC-EI-MS) in seized drug analysis. 



Funding for this Forensic Technology Center of Excellence report was provided by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice.

The opinions, findings, and conclusions or recommendations expressed in this report are those of the author(s) and do not necessarily reflect those of the U.S. Department of Justice.

Contact us at ForensicCOE@rti.org with any questions and subscribe to our newsletter for notifications.


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