Identify Synthetic Opioids using Ambient Ionization TOF-MS

Identify Synthetic Opioids using Ambient Ionization TOF-MS

← Back to Series 


This webinar will present the results of the evaluation of Direct Sample Analysis Time-of-Flight Mass Spectrometry to provide rapid identification of eighteen fentanyl analogs and related synthetic opioid.

As of March 2016, the Drug Enforcement Administration placed two fentanyl analogs (beta-hydroxythiofentanyl and butyryl fentanyl) under Schedule I of the Controlled Substance Act due to their imminent threat to public health. In June 2017, Acetyl Fentanyl was placed into Schedule I. These drugs elicit analgesic effects similar to heroin making them desirable drugs to abuse. Novel fentanyl analogs and designer opioids are expected to be more prominent in forensic casework in the near future. Many legal jurisdictions are acting to deal with the threat these compounds pose and have enacted changes in how criminal cases involving these drugs are handled. These drugs can be seen in forensic casework either alone or can be mixed with other drugs of abuse such as heroin. It is therefore necessary to have an efficient methodology to identify these compounds. In this study, Direct Sample Analysis Time-of-Flight Mass Spectrometry (DSA-TOFMS) was evaluated to provide rapid identification of eighteen fentanyl analogs and related synthetic opioids. Further, we will discuss policies surrounding the use, abuse, and analysis of these drugs.

A certificate of completion is available for all who register and attend this webinar.


  • Sabra R. Botch-Jones, MS, MA, D-ABFT-FT

Funding for this Forensic Technology Center of Excellence webinar has been provided by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice.

The opinions, findings, and conclusions or recommendations expressed in this webinar are those of the presenter(s) and do not necessarily reflect those of the U.S. Department of Justice.

Contact us at with any questions and subscribe to our newsletter for notifications.

Related Content

The Sentinel Role of Forensic Toxicology Laboratories to Identify and Act Upon Diverse Drug Threats by Addressing Toxicology and Economic Demands

Publication Forensic Science International: Synergy, September, 2022 Authors Jeri D. Ropero Miller | RTI International Lawrance D. Mullen | RTI International Paul J. Speaker | West Virginia University Introduction The societal costs from substance abuse are extensive and include treatment…

Medicolegal Death Investigation Partnerships on Overdose Fatality Reviews

Date July 2022 Overview The main purpose of Overdose Fatality Reviews (OFRs) is to review overdose fatalities and find gaps in services to help save lives. They rely on a multi-agency approach to information sharing to accomplish this goal. Upon…

Project ECHO: Applications for the Medicolegal Death Investigation Community and Other Forensic Disciplines

Date October 2022 Overview Similar to the foundational ECHO model designed for primary care providers, ECHO: Overdose Fatality Investigation Techniques (OD-FIT) is designed to promote the rapid dissemination of medicolegal death investigation-specific knowledge for immediate application to overdose casework.1 The ECHO…